Development of label-free bioaffinity sensor using a lumped-constant microwave resonator probe

Noriaki Okazaki, Taito Nishino, Toyohiro Chikyow, Yasuo Cho

研究成果: Article査読

抄録

A novel label-free bioaffinity sensor using a lumped-constant microwave resonator was developed. A gold probe with a spherical tip immobilizing anti-chicken egg albumin antibody or anti-human albumin antibody on its surface was connected to the resonator and inserted into a flow cell to monitor the target antigen binding. The sensor showed specific sensitivity against its target antigen evidenced by the change of resonance frequency after the antigen injection. The large frequency shift observed during the injection of antigen solution was ascribed to the change of solution dielectric constant which showed a systematic increase with antigen concentration.

本文言語English
論文番号017001
ジャーナルApplied Physics Express
4
1
DOI
出版ステータスPublished - 2011 1月 1

ASJC Scopus subject areas

  • 工学(全般)
  • 物理学および天文学(全般)

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