Development of high density immobilized biomolecule surface for high sensitivity clinical diagnosis device

Kazuki Nishizawa, Tomohiro Konno, Madoka Takai, Kazuhiko Ishihara

研究成果: Paper査読

抄録

We developed a new solid biointerface by integrating a phospholipid polymer (PMBN) with a nanoscale surface modification process known as the electrospray deposition (ESD) method. In the enzyme immunoassay using this surface, the sensitivity was significantly enhanced. The surface prepared by ESD was nanosphere-shaped structure, therefore the highly uneven surface causes a drastic increase in specific signals due to an increase in the surface area. The PMBN surface which can conjugate antibodies prevented the nonspecific protein adsorption. The stability of the antibodies immobilized on the PMBN surface was improved drastically. The PMBN surface sprayed by ESD can be used to yield a highly sensitive, stable, and reliable assay.

本文言語English
ページ5519-5520
ページ数2
出版ステータスPublished - 2006
外部発表はい
イベント55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
継続期間: 2006 9 202006 9 22

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
国/地域Japan
CityToyama
Period06/9/2006/9/22

ASJC Scopus subject areas

  • 工学(全般)

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