Development of asymmetric cycloaddition reaction using amino alcohol and its derivative as an organocatalyst

Hiroto Nakano, Jun Kumagai, U. V.Subba Reddy, Chigusa Seki, Yuko Okuyama, Eunsang Kwon

研究成果: Review article査読

4 被引用数 (Scopus)

抄録

The design of a chiral organocatalyst is very important for achievement of a high optical purity in a catalytic asymmetric reaction. Recently, we developed various chiral β-amino alcohol organocatalysts. These organocatalysts showed high levels of catalytic activity in the asymmetric Diels-Alder (DA) reactions of some dienes with dienophiles and 1,3-dipolar cycloaddition of some nitrones with α,β-unsaturated aldehydes, respectively. Especially, β-amino alcohols worked as organocatalyst in the DA reaction of 1,2-dihydropyridines with acroleins to afford the useful synthetic intermediate of Tamiflu. The review summarizes these our studies.

本文言語English
ページ(範囲)720-731
ページ数12
ジャーナルYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
74
7
DOI
出版ステータスPublished - 2016 1 1
外部発表はい

ASJC Scopus subject areas

  • Organic Chemistry

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