Development of a polyvinyl alcohol hydrogel for temperature measurement by MRI

Makoto Ohta, J. Paul Jacobson, Emile Hiltbrand, Alexis Kelekis, Marko Ivancevic, Daniel A. Rüfenacht, Hiroo Iwata, Sadami Tsutsumi

研究成果: Article査読

2 被引用数 (Scopus)


This paper describes the development of a Polyvinyl alcohol hydrogel (PVA-H) model for calibration and measurement of temperature using image contrast on MRI using DMSO/H2O as a solvent to alter the freezing and melting points of PVA-H. Tissues exposed to temperature changes above 41°C or below 0°C exhibit increasingly extensive and irreversible damage, depending on the exposure duration. MR images can provide a map of temperature if there is sufficient tissue signal. To evaluate treatment principles using temperature changes (hyperthermia, cryotherapy), a model simulating tissue may be useful to provide a reproducible test environment. PVA-H is water soluble and can be seen on MRI. It can be used to construct complicated shapes such as vascular structure, soft tissues, and so on. Therefore, PVA-H can be useful to measure temperatures and assume the distribution of temperature under treatment. In this paper, we applied PVA-H as a temperature detector and calibrated temperature from image contrast. The results exhibit good capability as a temperature detector not only of high temperature (around 41°C), but also of low temperature (as low as -23°C).

ジャーナルTechnology and Health Care
出版ステータスPublished - 2005 8月 23

ASJC Scopus subject areas

  • 生物理学
  • バイオエンジニアリング
  • 生体材料
  • 情報システム
  • 生体医工学
  • 健康情報学


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