Development of a method for cell delivery into the subretinal space using biodegradable nanosheets

Kazuya Yamashita, Hideto Kojima, Nobuhiro Nagai, Toshiaki Abe, Hirokazu Kaji

研究成果: Conference contribution

抄録

We investigated a minimally invasive and effective method for cell transplantation into the subretinal space. A biodegradable nanosheet as cell scaffold was fabricated from polycaprolactone (PCL) and collagen as low inflammatory materials and had sufficient strength and flexibility. Cell/nanosheet constructs were prepared by culturing cells on the nanosheets in a monolayer and injected into the subretinal space through the sclera of rat with a syringe needle. The cell/nanosheet construct was successively delivered into the subretinal space. This method holds great promise for transplantation of monolayer cells and for the development of local cell delivery systems.

本文言語English
ホスト出版物のタイトルMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
出版社Chemical and Biological Microsystems Society
ページ1264-1265
ページ数2
ISBN(電子版)9781733419017
出版ステータスPublished - 2020
イベント24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online
継続期間: 2020 10 42020 10 9

出版物シリーズ

名前MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
CityVirtual, Online
Period20/10/420/10/9

ASJC Scopus subject areas

  • 化学工学(その他)
  • バイオエンジニアリング
  • 化学 (全般)
  • 制御およびシステム工学

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