Development of a diketopiperazine-forming dipeptidyl Gly-Pro spacer for preparation of an antibody-drug conjugate

Shino Manabe, Hikaru Machida, Yoshiyuki Aihara, Masahiro Yasunaga, Yukishige Ito, Yasuhiro Matsumura

研究成果: Article査読

9 被引用数 (Scopus)

抄録

We developed a novel diketopiperazine-forming dipeptidyl spacer aimed at application in antibody-drug conjugates. Enzymatic cleavage of a peptide linked to the Gly-Pro spacer resulted in formation of diketopiperazine, which was stable and non-toxic, and release of the parent drug.

本文言語English
ページ(範囲)792-796
ページ数5
ジャーナルMedChemComm
4
5
DOI
出版ステータスPublished - 2013 5 1
外部発表はい

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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