Determination of phosphatidylcholine hydroperoxide (PCOOH) as a marker of membrane lipid peroxidation

研究成果: Review article査読

11 被引用数 (Scopus)

抄録

Increasing evidence for phosphatidylcholine hydroperoxide (PCOOH) as a marker of oxidative food deterioration and oxidative diseases has revealed the need for a pure PCOOH standard and a reliable quantification method. Recently, we synthesized the PCOOH isomers 1-palmitoyl-2-(9-hydroperoxyoctadecadienoyl)-sn-glycero-3-phosphocholine, (16:0/9-HpODE PC) and 1-palmitoyl-2-(13-hydroperoxyoctadecadienoyl)-sn-glycero-3-phosphocholine (16:0/13-HpODE PC). Using these standards along with liquid chromatography-tandem mass spectrometry, a reliable quantification method was developed. This mini-review describes these analytical techniques, with a particular emphasis on clinical sample analysis.

本文言語English
ページ(範囲)S78-S80
ジャーナルJournal of nutritional science and vitaminology
61
DOI
出版ステータスPublished - 2015 11 24

ASJC Scopus subject areas

  • 医学(その他)
  • 栄養および糖尿病

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