Designer hydrophilic regions regulate droplet shape for controlled surface patterning and 3D microgel synthesis

Matthew J. Hancock, Fumiki Yanagawa, Yun Ho Jang, Jiankang He, Nezamoddin N. Kachouie, Hirokazu Kaji, Ali Khademhosseini

研究成果: Article査読

37 被引用数 (Scopus)

抄録

A simple technique is presented for controlling the shapes of micro- and nanodrops by patterning surfaces with special hydrophilic regions surrounded by hydrophobic boundaries. Finite element method simulations link the shape of the hydrophilic regions to that of the droplets. Shaped droplets are used to controllably pattern planar surfaces and microwell arrays with microparticles and cells at the micro- and macroscales. Droplets containing suspended sedimenting particles, initially at uniform concentration, deposit more particles under deeper regions than under shallow regions. The resulting surface concentration is thus proportional to the local fluid depth and agrees well with the measured and simulated droplet profiles. A second application is also highlighted in which shaped droplets of prepolymer solution are crosslinked to synthesize microgels with tailored 3D geometry.

本文言語English
ページ(範囲)393-403
ページ数11
ジャーナルSmall
8
3
DOI
出版ステータスPublished - 2012 2 6

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

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