Design of a novel HIV-1 fusion inhibitor that displays a minimal interface for binding affinity

Shinya Oishi, Saori Ito, Hiroki Nishikawa, Kentaro Watanabe, Michinori Tanaka, Hiroaki Ohno, Kazuki Izumi, Yasuko Sakagami, Eiichi Kodama, Masao Matsuoka, Nobutaka Fujii

研究成果: Article査読

53 被引用数 (Scopus)

抄録

Reported herein are the design, biological activities, and biophysical properties of a novel HIV-1 membrane fusion inhibitor. α-Helix-inducible X-EE-XX-KK motifs were applied to design an enfuvirtide analogue 2 that exhibited highly potent anti-HIV activity against wild-type HIV-1, enfuvirtide-resistant HIV-1 strains, and an HIV-2 strain in vitro. Indispensable residues for bioactivity of enfuvirtide, including the residues interacting with the N-terminal heptad repeat and the C-terminal hydrophobic residues, were identified.

本文言語English
ページ(範囲)388-391
ページ数4
ジャーナルJournal of Medicinal Chemistry
51
3
DOI
出版ステータスPublished - 2008 2月 14
外部発表はい

ASJC Scopus subject areas

  • 分子医療
  • 創薬

フィンガープリント

「Design of a novel HIV-1 fusion inhibitor that displays a minimal interface for binding affinity」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル