@article{3a10c9a10bd1420ab50377f82c69f218,
title = "Design and synthesis of the penta(acetoxymethyl) ester of dioctanoyl phosphatidylinositol-3,5-bisphosphate",
abstract = "Extracellular administration of water-soluble and membrane-permeant analogs of phosphatidylinositol phosphates (PIPs) is a useful strategy for understanding the cellular roles of PIPs as well as the mode of action of drugs whose biological activity is associated with PIPs. We herein established the synthetic route to the dioctanoyl analogue of phosphatidylinositol 3,5-bisphosphate (di-C8-PI(3,5)P2) and its penta(acetoxymethyl) ester (di-C8-PI(3,5)P2/5AM).",
keywords = "Acetoxymethyl ester, Chemical synthesis, Dioctanoyl analog, Phosphatidylinositol 3,5-bisphosphates",
author = "Naoki Kanoh and Kosuke Mano and Daisuke Saigusa and Takeo Usui and Yoshiharu Iwabuchi",
note = "Funding Information: This work was partially supported by a Grant-in-Aid for Scientific Research on the Innovative Area {\textquoteleft}Chemical Biology of Natural Products{\textquoteright} (No. 23102013 to NK) from The Ministry of Education, Culture, Sports, Science and Technology, Japan, and the Platform Project for Supporting in Drug Discovery and Life Science Research (Platform for Drug Discovery, Informatics, and Structural Life Science) from the Japan Agency for Medical Research and Development. Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",
year = "2016",
doi = "10.1016/j.bmcl.2016.10.046",
language = "English",
volume = "26",
pages = "5770--5772",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "23",
}