Design and synthesis of simplified polycyclic ethers and evaluation of their interaction with an α-helical peptide as a model of target proteins

Masato Sasaki, Kazuo Tachibana

研究成果: Article査読

14 被引用数 (Scopus)

抄録

Two simplified pentacyclic ethers, having 6/7/6/6/7 and 6/7/6/7/7 ring systems, were synthesized. A convergent route based on the Suzuki-Miyaura cross-coupling strategy was applied to synthesize these two compounds. Interactions between α-helical peptide, melittin, and synthesized pentacyclic ethers were evaluated by circular dichroism (CD) spectroscopy. Interestingly, only the polycyclic ether having a 6/7/6/7/7 ring stabilized the α-helical structure of melittin. This result indicated that a ring fusion manner of the polycyclic structure is important to recognize membrane proteins.

本文言語English
ページ(範囲)3181-3186
ページ数6
ジャーナルTetrahedron Letters
48
18
DOI
出版ステータスPublished - 2007 4 30
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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