Design and application of ion-channel sensors based on biological and artificial receptors

Masao Sugawara, Ayumi Hirano, Philippe Bühlmann, Yoshio Umezawa

研究成果: Review article査読

53 被引用数 (Scopus)

抄録

This paper reviews approaches to chemical sensing with receptor-modified electrodes that mimic the function of natural membranes containing biological and synthetic receptor channels. We highlight different types of ion-channel sensors, focusing on the working principle and the fundamental aspects, such as sensitivity and selectivity. It is demonstrated that biological receptors such as glutamate receptor ion channels and gramicidin, embedded in bilayer lipid membranes, have the potential as sensing elements for ion channel sensors with excellent sensitivity and selectivity. In addition, higher selectivities by improved receptor desigh, taking into account the particular advantages of interfacial analyte recognition at LB membranes and SAMs, are also shown with ion-channel sensors for antibodies, protamine, heparin, abasic DNA sites, and oligonucleotides.

本文言語English
ページ(範囲)187-201
ページ数15
ジャーナルBulletin of the Chemical Society of Japan
75
2
DOI
出版ステータスPublished - 2002 3 14
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)

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