Derivatization of a tris-oxazole using Pd-catalyzed coupling reactions of a 5-bromooxazole moiety

Kazuaki Shibata, Masahito Yoshida, Takayuki Doi, Takashi Takahashi

研究成果: Article査読

21 被引用数 (Scopus)

抄録

Modification at the C5 position of an oxazole ring contained in a 2,4-concatenated tris-oxazole by Pd-catalyzed coupling reactions was performed. Novel Pd-catalyzed amination and alkoxylation of a 5-bromooxazole derivative as well as Suzuki-Miyaura coupling and Migita-Stille coupling have been demonstrated. A wide variety of functional groups, including aryl, heteroaryl, primary and secondary amines, and phenol, were introduced in the 5-bromooxazole moiety in moderate to excellent yields using Pd(OAc)2/S-PHOS or Pd(OAc)2/X-PHOS as a catalyst.

本文言語English
ページ(範囲)1674-1677
ページ数4
ジャーナルTetrahedron Letters
51
13
DOI
出版ステータスPublished - 2010 3月 31

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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