Dependence of Baroreceptor‐Mediated Sympathetic Outflow on Biventricular Assist Device Driving Frequency

Tomoyuki Yambe, Shin‐ichi ‐i Nitta, Yoshiaki Katahira, Taroh Sonobe, Shigeru Naganuma, Yoshito Kakinuma, Hiroshi Akiho, Kenji Izutsu, Yuhichi Kikuchi, Motonao Tanaka, Makoto Miura, Naoshi Sato, Hitoshi Mohri, Makoto Yoshizawa, Kyou‐ichiroh ‐i Izumi, Hiroshi Takeda

研究成果: Article査読

3 被引用数 (Scopus)


Abstract: To investigate the drive condition of the artificial heart from a neurophysiological point of view, the dynamic transduction characteristics of the baroreflex system were analyzed by means of sympathetic neurograms. Two pneumatically actuated ventricular assist devices were implanted as biventricular bypasses (BVBs) in adult mongrel dogs to compare the natural heart circulation and prosthetic circulation. After BVB pumping was initiated, the natural heart was electrically fibrillated. Renal sympathetic nerve activity (RSNA) was recorded to analyze sympathetic outflow. Coherence function between the arterial pressure and RSNA was calculated to evaluate the linearity of the baroreflex system. The largest peak coherency was observed when BVB was driven at the frequency of natural heart beat prior to electrical fibrillation, which suggests that the baroreflex system shows the largest linearity at this frequency. These results suggest the possibility that the natural heart heat frequency is the setting frequency at which the baroreflex system transfers the hemodynamic rhythm to the sympathetic outflow.

ジャーナルArtificial Organs
出版ステータスPublished - 1993 1

ASJC Scopus subject areas

  • バイオエンジニアリング
  • 医学(その他)
  • 生体材料
  • 生体医工学


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