Dendritic Eph organizes dendrodendritic segregation in discrete olfactory map formation in Drosophila

Marie Anzo, Sayaka Sekine, Shirin Makihara, Kinhong Chao, Masayuki Miura, Takahiro Chihara

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Proper function of the neural network results from the precise connections between axons and dendrites of presynaptic and postsynaptic neurons, respectively. In the Drosophila olfactory system, the dendrites of projection neurons (PNs) stereotypically target one of ∼50 glomeruli in the antennal lobe (AL), the primary olfactory center in the brain, and form synapses with the axons of olfactory receptor neurons (ORNs). Here, we show that Eph and Ephrin, the well-known axon guidance molecules, instruct the dendrodendritic segregation during the discrete olfactory map formation. The Eph receptor tyrosine kinase is highly expressed and localized in the glomeruli related to reproductive behavior in the developing AL. In one of the pheromone-sensing glomeruli (DA1), the Eph cell-autonomously regulates its dendrites to reside in a single glomerulus by interacting with Ephrins expressed in adjacent PN dendrites. Our data demonstrate that the trans interaction between dendritic Eph and Ephrin is essential for the PN dendritic boundary formation in the DA1 olfactory circuit, potentially enabling strict segregation of odor detection between pheromones and the other odors.

本文言語English
ページ(範囲)1054-1065
ページ数12
ジャーナルGenes and Development
31
10
DOI
出版ステータスPublished - 2017 5月 15
外部発表はい

ASJC Scopus subject areas

  • 遺伝学
  • 発生生物学

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