Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats

Shiro Yamanouchi; Takao Shimazoe; Seiko Nagata; Takahiro Moriya; Miyuki Maetani; Shigenobu Shibata; Shigenori Watanabe; Kyoko Miyasaka; Akira Kono; Akihiro Funakoshi

doi:10.1016/S0304-3940(97)00324-8

Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats

Shiro Yamanouchi, Takao Shimazoe, Seiko Nagata, Takahiro Moriya, Miyuki Maetani, Shigenobu Shibata, Shigenori Watanabe, Kyoko Miyasaka, Akira Kono, Akihiro Funakoshi

薬学研究科・医療薬学専攻

研究成果: Article › 査読

17 被引用数 (Scopus)

抄録

We assessed light-induced Fos-immunoreactive cells in the suprachiasmatic nucleus of diabetic rats. The number of Fos-immunoreactive cells significantly decreased in diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats as compared with control Long-Evans Tokushima Otsuka (LETO) rats. In contrast there was no decrease in the number of Fos-immunoreactive cells in young OLETF rats which have not yet developed diabetes. Two months after the administration of streptozotocin (STZ) to Wistar rats, the number of Fos-immunoreactive cells significantly decreased, although 1 week after the administration of STZ, the number had not yet changed in these STZ- induced diabetic rats. These results suggest that chronic diabetic (hyperglycemic) conditions may affect the light entraining responses in the suprachiasmatic nucleus (SCN).

本文言語	English
ページ（範囲）	103-106
ページ数	4
ジャーナル	Neuroscience Letters
巻	227
号	2
DOI	https://doi.org/10.1016/S0304-3940(97)00324-8
出版ステータス	Published - 1997 5 16

ASJC Scopus subject areas

Neuroscience(all)

文献へのアクセス

10.1016/S0304-3940(97)00324-8

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引用スタイル

Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats. / Yamanouchi, Shiro; Shimazoe, Takao; Nagata, Seiko; Moriya, Takahiro; Maetani, Miyuki; Shibata, Shigenobu; Watanabe, Shigenori; Miyasaka, Kyoko; Kono, Akira; Funakoshi, Akihiro.

In: Neuroscience Letters, Vol. 227, No. 2, 16.05.1997, p. 103-106.

研究成果: Article › 査読

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abstract = "We assessed light-induced Fos-immunoreactive cells in the suprachiasmatic nucleus of diabetic rats. The number of Fos-immunoreactive cells significantly decreased in diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats as compared with control Long-Evans Tokushima Otsuka (LETO) rats. In contrast there was no decrease in the number of Fos-immunoreactive cells in young OLETF rats which have not yet developed diabetes. Two months after the administration of streptozotocin (STZ) to Wistar rats, the number of Fos-immunoreactive cells significantly decreased, although 1 week after the administration of STZ, the number had not yet changed in these STZ- induced diabetic rats. These results suggest that chronic diabetic (hyperglycemic) conditions may affect the light entraining responses in the suprachiasmatic nucleus (SCN).",

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author = "Shiro Yamanouchi and Takao Shimazoe and Seiko Nagata and Takahiro Moriya and Miyuki Maetani and Shigenobu Shibata and Shigenori Watanabe and Kyoko Miyasaka and Akira Kono and Akihiro Funakoshi",

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AU - Moriya, Takahiro

AU - Maetani, Miyuki

AU - Shibata, Shigenobu

AU - Watanabe, Shigenori

AU - Miyasaka, Kyoko

AU - Kono, Akira

AU - Funakoshi, Akihiro

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N2 - We assessed light-induced Fos-immunoreactive cells in the suprachiasmatic nucleus of diabetic rats. The number of Fos-immunoreactive cells significantly decreased in diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats as compared with control Long-Evans Tokushima Otsuka (LETO) rats. In contrast there was no decrease in the number of Fos-immunoreactive cells in young OLETF rats which have not yet developed diabetes. Two months after the administration of streptozotocin (STZ) to Wistar rats, the number of Fos-immunoreactive cells significantly decreased, although 1 week after the administration of STZ, the number had not yet changed in these STZ- induced diabetic rats. These results suggest that chronic diabetic (hyperglycemic) conditions may affect the light entraining responses in the suprachiasmatic nucleus (SCN).

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KW - Diabetes

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KW - Suprachiasmatic nucleus

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