Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats

Shiro Yamanouchi, Takao Shimazoe, Seiko Nagata, Takahiro Moriya, Miyuki Maetani, Shigenobu Shibata, Shigenori Watanabe, Kyoko Miyasaka, Akira Kono, Akihiro Funakoshi

研究成果: Article査読

17 被引用数 (Scopus)

抄録

We assessed light-induced Fos-immunoreactive cells in the suprachiasmatic nucleus of diabetic rats. The number of Fos-immunoreactive cells significantly decreased in diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats as compared with control Long-Evans Tokushima Otsuka (LETO) rats. In contrast there was no decrease in the number of Fos-immunoreactive cells in young OLETF rats which have not yet developed diabetes. Two months after the administration of streptozotocin (STZ) to Wistar rats, the number of Fos-immunoreactive cells significantly decreased, although 1 week after the administration of STZ, the number had not yet changed in these STZ- induced diabetic rats. These results suggest that chronic diabetic (hyperglycemic) conditions may affect the light entraining responses in the suprachiasmatic nucleus (SCN).

本文言語English
ページ(範囲)103-106
ページ数4
ジャーナルNeuroscience Letters
227
2
DOI
出版ステータスPublished - 1997 5 16

ASJC Scopus subject areas

  • Neuroscience(all)

フィンガープリント 「Decreased level of light-induced Fos expression in the suprachiasmatic nucleus of diabetic rats」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル