Decreased brain histamine content in hypocretin/orexin receptor-2 mutated narcoleptic dogs

Seiji Nishino, Nobuhiro Fujiki, Beth Ripley, Eiko Sakurai, Motohisa Kato, Takehiko Watanabe, Emmanuel Mignot, Kazuhiko Yanai

研究成果: Article査読

111 被引用数 (Scopus)

抄録

A growing amount of evidence suggests that a deficiency in hypocretin/orexin neurotransmission is critically involved in animal and human forms of narcolepsy. Since hypocretin-containing neurons innervate and excite histaminergic tuberomammillary neurons, altered histaminergic neurotransmission may also be involved in narcolepsy. We found a significant decrease in histamine content in the cortex and thalamus, two structures important for histamine-mediated cortical arousal, in Hcrtr-2 mutated narcoleptic Dobermans. In contrast, dopamine and norepinephrine contents in these structures were elevated in narcoleptic animals, a finding consistent with our hypothesis of altered catecholaminergic transmission in these animals. Considering the fact that histamine promotes wakefulness, decreases in histaminergic neurotransmission may also account for the sleep abnormalities in hypocretin-deficient narcolepsy.

本文言語English
ページ(範囲)125-128
ページ数4
ジャーナルNeuroscience Letters
313
3
DOI
出版ステータスPublished - 2001 11 9

ASJC Scopus subject areas

  • 神経科学(全般)

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