Decreased a disintegrin-like and metalloprotease with thrombospondin type 1 motif 13 activity and neurologic outcome in patients with successful resuscitation of out-of-hospital cardiac arrest: A prospective observational study

Hiroyuki Ohbe, Daisuke Kudo, Satoshi Yamanouchi, Shigeki Kushimoto

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Purpose The purpose of this study is to investigate the association between a disintegrin-like and metalloprotease with thrombospondin type 1 motif 13 (ADAMTS13) and neurologic outcome in patients with resuscitation of out-of-hospital cardiac arrest (R-OHCA). Materials and Methods A prospective observational study of adult patients with R-OHCA was conducted. Plasma activity of ADAMTS13 and inflammatory markers, an immunologic marker, and a marker of endothelial damage were measured on admission and day 2. Neurologic outcome was evaluated using the Cerebral Performance Categories on day 90. Results Plasma activity of ADAMTS13 on day 2 was lower in patients with poor neurologic outcome (n = 18) than that in those with good neurologic outcome (n = 16; P =.008). It was also lower in 28-day nonsurvivors (n = 12) than in survivors (n = 21; P =.019). Soluble thrombomodulin showed a strong correlation with ADAMTS13 (P =.021). Furthermore, ADAMTS13 activity was negatively correlated with the Sequential Organ Failure Assessment score (P <.001), levels of high-mobility group box 1 (P =.028), and levels of interleukin 6 (P =.047) but positively correlated with the monocyte expression of human leukocyte antigen DR (P =.023). Conclusion Decreased ADAMTS13 activity was associated with poor neurologic outcome, high mortality, and worsened immune-inflammatory status in patients with R-OHCA. These results suggest that ADAMTS13 may have pathophysiologic relevance in postcardiac arrest syndrome.

本文言語English
ページ(範囲)13-18
ページ数6
ジャーナルJournal of Critical Care
37
DOI
出版ステータスPublished - 2017 2 1

ASJC Scopus subject areas

  • 集中医療医学

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