Data descriptor: Global transcriptome analysis of pig induced pluripotent stem cells derived from six and four reprogramming factors

Tomokazu Fukuda, Koji Doi, Kenichiro Donai, Kouhei Takahashi, Hisato Kobayashi, Takashi Hirano, Katsuhiko Nishimori, Hiroshi Yasue

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Pigs are important, both for agriculture and as animal models for human diseases. However, due to the lack of embryonic stem cells, the possibility of genetic modification is quite limited. To overcome this limitation, induced pluripotent stem (iPS) cells have been derived from pigs. Despite the public availability of a large number of expression datasets from mice, rats, and primates-derived iPS cells, the expression profile of pig-derived iPS cells is quite limited. Furthermore, there is no dataset focused on the profiling of pig-derived iPS cell with six reprogramming factors (Oct3/4, Sox2, Klf4, c-Myc, Lin28, and Nanog). Here, we used Illumina RNA sequencing platform to characterize the mRNA expression of four-factor derived and six-factor derived pig iPS cells. We observed that the expression levels of whole genes in our established six factors derived iPS cells and parent fibroblast, and compared with that of iPS cells with four factors in public database. These data are valuable in understanding species difference in the reprogramming process of stem cells, and could help identify the key regulating genes involved in the process.

本文言語English
論文番号190034
ジャーナルScientific Data
6
DOI
出版ステータスPublished - 2019

ASJC Scopus subject areas

  • 統計学および確率
  • 情報システム
  • 教育
  • コンピュータ サイエンスの応用
  • 統計学、確率および不確実性
  • 図書館情報学

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