Damage to DNA strand and the effects of anticancer drugs.

R. Kanamaru, C. Ishioka, Y. Konishi, A. Ishikawa, H. Shibata, A. Wakui

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Cancer chemotherapy is, in a sense, similar to the treatment of infectious disease with antibiotics. The main mechanism of action is on DNA and its precursor, and in the process that anticancer drugs exert the effect on cancer cells, the cells always have abnormal metabolism or destruction of DNA. The main cellular target of most alkylating agents, or anticancer antibiotics is DNA, however, among the anticancer drug newly synthesized, there are some compounds which exert the action on DNA. Quinocarmycin, KT6149, which is a derivative of MMC, YM534, which possesses a platelet agglutinating activity, and MCNU, a nitrosourea compound were studied on the anticancer activity and on damage to DNA strand, and it was found that the lethal effect was deeply concerned with single strand scission of DNA.

本文言語English
ページ(範囲)29-36
ページ数8
ジャーナルScience Reports of the Research Institutes Tohoku University - Series C Medicine
36
1-4
出版ステータスPublished - 1989 12
外部発表はい

ASJC Scopus subject areas

  • 医学(全般)

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