Daam1 regulates the endocytosis of EphB during the convergent extension of the zebrafish notochord

Yasuyuki S. Kida, Takayuki Sato, Kota Miyasaka, Asami Suto, Toshihiko Ogura

研究成果: Article査読

52 被引用数 (Scopus)

抄録

Convergent extension (CE) movement of cells is one of the fundamental processes that control the organized morphogenesis of tissues and organs. The molecular events connecting the noncanonical Wnt pathway and CE movement, however, are not well understood. We show that subcellular localization of Daam1, an essential component of noncanonical Wnt signaling, changes dynamically during notochord formation. In the early phases, Daam1 complexes with EphB receptors and Disheveled 2. This complex is incorporated into endocytic vesicles in a dynamin-dependent manner, thereby resulting in the removal of EphB from the cell surface with subsequent switching of cell adhesiveness. In the next step, Daam1 colocalizes with the actin cytoskeleton to induce morphological extension of cells. We elucidate the molecular mechanism underlying the CE movement of notochord cells with Daam1 as a dynamic coordinator of endocytosis and cytoskeletal remodeling.

本文言語English
ページ(範囲)6708-6713
ページ数6
ジャーナルProceedings of the National Academy of Sciences of the United States of America
104
16
DOI
出版ステータスPublished - 2007 4月 17

ASJC Scopus subject areas

  • 一般

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