Cytotoxicity evaluation of graphene oxide against adherent and suspension cancer cells

Thabang C. Lebepe, Sundararajan Parani, Ncapayi Vuyelwa, Tetsuya Kodama, Oluwatobi S. Oluwafemi

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Graphene oxide (GO) has been very useful in many applications however little is known about its toxicity in biological applications. Herein, we report the synthesis of GO and its cytotoxicity against four cancer (adherent and suspension) cell lines namely fibroblast histiocytoma (KM-Luc/GFP), breast (FM3A-Luc), ovarian (OV 2944-HM-1) and fibrosarcoma (NFSaY83). The as-synthesized GO is highly dispersible in water with good optical and structural properties. The cytotoxicity evaluation indicated that the as-prepared GO displayed high cell viability against all the four cancer cell lines and its action was very selective at very high concentration (500 µg/mL) with no significant toxicity towards FM3A-Luc and OV 2944-HM-1 at all concentrations.

本文言語English
論文番号128470
ジャーナルMaterials Letters
279
DOI
出版ステータスPublished - 2020 11月 15

ASJC Scopus subject areas

  • 材料科学(全般)
  • 凝縮系物理学
  • 材料力学
  • 機械工学

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