Cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled rheumatoid arthritis

Vassilis Aidinis, Piero Carninci, Maria Armaka, Walter Witke, Vaggelis Harokopos, Norman Pavelka, Dirk Koczan, Christos Argyropoulos, Maung Maung Thwin, Steffen Möller, Waki Kazunori, Ponnampalam Gopalakrishnakone, Paola Ricciardi-Castagnoli, Hans Jürgen Thiesen, Yoshihide Hayashizaki, George Kollias

研究成果: Article査読

42 被引用数 (Scopus)

抄録

Rheumatoid arthritis is a chronic inflammatory disease with a high prevalence and substantial socioeconomic burden. Despite intense research efforts, its aetiology and pathogenesis remain poorly understood. To identify novel genes and/or cellular pathways involved in the pathogenesis of the disease, we utilized a well-recognized tumour necrosis factor-driven animal model of this disease and performed high-throughput expression profiling with subtractive cDNA libraries and oligonucleotide microarray hybridizations, coupled with independent statistical analysis. This twin approach was validated by a number of different methods in other animal models of arthritis as well as in human patient samples, thus creating a unique list of disease modifiers of potential therapeutic value. Importantly, and through the integration of genetic linkage analysis and Gene Ontology-assisted functional discovery, we identified the gelsolin-driven synovial fibroblast cytoskeletal rearrangements as a novel pathophysiological determinant of the disease.

本文言語English
ページ(範囲)455-466
ページ数12
ジャーナルPLoS Genetics
1
4
DOI
出版ステータスPublished - 2005

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Genetics(clinical)
  • Cancer Research

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