Cytokine-induced enhancement of calcium-dependent glutamate release from astrocytes mediated by nitric oxide

Tomoaki Ida, Masayuki Hara, Yoichi Nakamura, Shunji Kozaki, Shigeru Tsunoda, Hideshi Ihara

研究成果: Article査読

90 被引用数 (Scopus)

抄録

Cytokines are produced in the central nervous system (CNS) and exhibit various effects on neurons, microglia, and astrocytes. Astrocytes can release chemical transmitters, including glutamate, in a calcium-dependent manner, which may mediate communication between neurons and astrocytes. To date, no studies have been conducted on the effects of cytokines on calcium-dependent glutamate release from astrocytes. Here, we studied the effects of cytokines on calcium-dependent glutamate release. Cytokines enhanced glutamate release and induced the expression of inducible nitric oxide synthase (iNOS) and the production of nitric oxide (NO). The inhibition of iNOS eliminated the cytokine-induced enhancement of glutamate release, and treatment with a NO donor, even in the absence of cytokines, increased glutamate release. Thus, cytokines enhance glutamate release, and this enhancement is mediated by NO.

本文言語English
ページ(範囲)232-236
ページ数5
ジャーナルNeuroscience Letters
432
3
DOI
出版ステータスPublished - 2008 2月 27
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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