Cyclin' toward dementia: Cell cycle abnormalities and abortive oncogenesis in Alzheimer disease

Arun K. Raina, Xiongwei Zhu, Catherine A. Rottkamp, Mervyn Monteiro, Atsushi Takeda, Mark A. Smith

研究成果: Short survey査読

145 被引用数 (Scopus)

抄録

Recent evidence has associated the aberrant, proximal re-expression of various cell cycle control elements with neuronal vulnerability in Alzheimer disease, a chronic neurodegeneration. Such ectopic localization of various cyclins, cyclin-dependent kinases, and cyclin inhibitors in neurons can be seen as an attempt to re-enter the cell cycle. Given that primary neurons are terminally differentiated, any attempted re-entry into the cell division cycle in this postmitotic environment will be dysregulated. Since successful dysregulation of the cell cycle is also the hallmark of a neoplasm, early cell-cycle pathophysiology in Alzheimer disease may recruit oncogenic signal transduction mechanisms and, hence, can be viewed as an abortive neoplastic transformation. (C) 2000 Wiley-Liss, Inc.

本文言語English
ページ(範囲)128-133
ページ数6
ジャーナルJournal of Neuroscience Research
61
2
DOI
出版ステータスPublished - 2000 7 15
外部発表はい

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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