Cyclic ADP-ribose modulates Ca2+ release channels for activation by physiological Ca2+ entry in bullfrog sympathetic neurons

Shao Ying Hua, Takayuki Tokimasa, Shin Takasawa, Yasuhito Furuya, Mitsuo Nohmi, Hiroshi Okamoto, Kenji Kuba

研究成果: Article査読

121 被引用数 (Scopus)

抄録

Although Ca2+-induced Ca2+ release (CICR) via ryanodine receptors has been found to occur in intact neurons, little is known about the physiological processes that regulate it. We studied the effects of cyclic ADP-ribose (cADPR) on CICR in cultured bullfrog sympathetic neurons by fura-2 fluorescence recording and patch-clamp techniques. cADPR applied through a patch pipette augmented action potential- or depolarizing pulse-induced rises in intracellular Ca2+ without a change in Ca2+ entry initiating the responses, but not in the presence of ryanodine. Likewise, cADPR enhanced a single or oscillatory rise(s) in intracellular Ca2+ induced by caffeine. These results strongly suggest that cADPR can be an endogenous modulator of ryanodine receptors in neurons.

本文言語English
ページ(範囲)1073-1079
ページ数7
ジャーナルNeuron
12
5
DOI
出版ステータスPublished - 1994 5

ASJC Scopus subject areas

  • 神経科学(全般)

フィンガープリント

「Cyclic ADP-ribose modulates Ca<sup>2+</sup> release channels for activation by physiological Ca<sup>2+</sup> entry in bullfrog sympathetic neurons」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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