CSF-chemokines in HTLV-I-associated myelopathy: CXCL10 up-regulation and therapeutic effect of interferon-α

Koichi Narikawa, Kazuo Fujihara, Tatsuro Misu, Juan Feng, Juichi Fujimori, Ichiro Nakashima, Isabelle Miyazawa, Hiroshi Saito, Shigeru Sato, Yasuto Itoyama

研究成果: Article査読

28 被引用数 (Scopus)

抄録

We measured four chemokines in the cerebrospinal fluid (CSF) in human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) with ELISA. CXCL10/IP-10, a T cell type 1 (Th1)-associated chemokine, was significantly elevated in HAM/TSP compared with controls, and the values were even significantly higher in HAM/TSP than in multiple sclerosis (MS) in which CXCL10/IP-10 up-regulation was previously reported. Among Th2-associated chemokines, CCL17/TARC and CCL11/Eotaxin in HAM/TSP were not different from those in controls. As shown in MS, CCL2/MCP-1 was significantly lower in HAM/TSP than in control. Following interferon (IFN)-α therapy in HAM/TSP, CCL2/MCP-1 became significantly higher than that before therapy, which may reflect a Th2 induction, while CXCL10/IP-10 remained elevated.

本文言語English
ページ(範囲)177-182
ページ数6
ジャーナルJournal of Neuroimmunology
159
1-2
DOI
出版ステータスPublished - 2005 2月

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学
  • 神経学
  • 臨床神経学

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