Crystal structure of chalcone synthase, a key enzyme for isoflavonoid biosynthesis in soybean

Riki Imaizumi, Ryo Mameda, Kohei Takeshita, Hiroki Kubo, Naoki Sakai, Shun Nakata, Seiji Takahashi, Kunishige Kataoka, Masaki Yamamoto, Toru Nakayama, Satoshi Yamashita, Toshiyuki Waki

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Isoflavonoid is one of the groups of flavonoids that play pivotal roles in the survival of land plants. Chalcone synthase (CHS), the first enzyme of the isoflavonoid biosynthetic pathway, catalyzes the formation of a common isoflavonoid precursor. We have previously reported that an isozyme of soybean CHS (termed GmCHS1) is a key component of the isoflavonoid metabolon, a protein complex to enhance efficiency of isoflavonoid production. Here, we determined the crystal structure of GmCHS1 as a first step of understanding the metabolon structure, as well as to better understand the catalytic mechanism of GmCHS1.

本文言語English
ジャーナルProteins: Structure, Function and Bioinformatics
DOI
出版ステータスAccepted/In press - 2020

ASJC Scopus subject areas

  • 構造生物学
  • 生化学
  • 分子生物学

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