Cross-Regulation of an Artificial Metalloenzyme

Yasunori Okamoto, Thomas R. Ward

研究成果: Article査読

17 被引用数 (Scopus)

抄録

Cross-regulation of complex biochemical reaction networks is an essential feature of living systems. In a biomimetic spirit, we report on our efforts to program the temporal activation of an artificial metalloenzyme via cross-regulation by a natural enzyme. In the presence of urea, urease slowly releases ammonia that reversibly inhibits an artificial transfer hydrogenase. Addition of an acid, which acts as fuel, allows to maintain the system out of equilibrium.

本文言語English
ページ(範囲)10156-10160
ページ数5
ジャーナルAngewandte Chemie - International Edition
56
34
DOI
出版ステータスPublished - 2017 8月 14
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

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