Critical role of cortactin in actin ring formation and osteoclastic bone resorption

Takuma Matsubara, Akira Myoui, Fumiyo Ikeda, Kenji Hata, Hideki Yoshikawa, Riko Nishimura, Toshiyuki Yoneda

    研究成果: Article査読

    20 被引用数 (Scopus)

    抄録

    Tyrosine kinase c-Src plays an essential role in ruffled border formation and bone resorption in osteoclasts; however, it is unclear how c-Src controls ruffled border formation during bone resorption. To address this question, we investigated the role of cortactin, a c-Src substrate, in osteoclasts. We found that cortactin showed colocalization with c-Src and actin rings in osteoclasts. Overexpression of cortactin stimulated actin ring formation in RAW 264.7 cells. In contrast, overexpression of Csk inhibited tyrosine phosphorylation of cortactin and binding of cortactin to c-Src. More importantly, overexertion of a mutant cortactin strongly suppressed actin ring formation and bone resorbing activity in osteoclasts. Collectively, our data indicate that cortactin controls osteoclastic bone resorption by regulating actin organization.

    本文言語English
    ページ(範囲)368-372
    ページ数5
    ジャーナルJournal of Bone and Mineral Metabolism
    24
    5
    DOI
    出版ステータスPublished - 2006 9月

    ASJC Scopus subject areas

    • 内分泌学、糖尿病および代謝内科学
    • 整形外科およびスポーツ医学
    • 内分泌学

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