Creation of pure nanodrugs and their anticancer properties

Hitoshi Kasai, Tatsuya Murakami, Yoshikazu Ikuta, Yoshitaka Koseki, Koichi Baba, Hidetoshi Oikawa, Hachiro Nakanishi, Masahiro Okada, Mitsuru Shoji, Minoru Ueda, Hiroshi Imahori, Mitsuru Hashida

研究成果: Article査読

102 被引用数 (Scopus)

抄録

A method for preparing nanoparticles of a water-insoluble drug that are suitable for administration to the human body has been established. A reprecipitation method was used to fabricate 50 nm nanoparticles of dimerized SN-38, an anticancer camptothecin derivative, that form stable aqueous dispersions and can penetrate into cancer cells to inhibit cell proliferation more potently than irinotecan.

本文言語English
ページ(範囲)10315-10318
ページ数4
ジャーナルAngewandte Chemie - International Edition
51
41
DOI
出版ステータスPublished - 2012 10 8

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

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