Cortical bone tissue response of injectable octacalcium phosphate-hyaluronic acid complexes

Kentaro Suzuki, Takahisa Anada, Yoshitomo Honda, Koshi N. Kishimoto, Naohisa Miyatake, Masami Hosaka, Hideki Imaizumi, Eiji Itoi, Osamu Suzuki

研究成果: Conference contribution

7 被引用数 (Scopus)

抄録

We have previously shown that synthetic octacalcium phosphate (OCP) displays highly osteoconductive and biodegradable characteristics. However, OCP cannot be sintered without thermal decomposition due to the existence of water molecules in the structure. The acquisition of the moldability and the improvement of the handling property in this material are subjects for the clinical use. In the present study, we prepared OCP complex with hyaluronic acid (Hya) that could be used in the injectable form and further examined the bone tissue reaction to cortical bone by placing the complex directly on an 8-weeks-old ICR mouse calvaria in comparison with the placement of OCP granules only. The granule form of OCP (between 300 to 500 μm in diameter) was mixed with sodium hyaluronic acid with molecular weights 90 x 104. The complex revealed an injectable characteristic if it was utilized in a syringe. After polytetrafluoroethylen ring was mounted on mouse calvaria, the inner space of the ring was filled with the complex and left the complex as it is for 6 weeks. Histological examination using the decalcified specimens indicated that the OCP/Hya complex exhibited greater bone formation than OCP granules only group within the ring at 6 weeks. The results suggested that the OCP/Hya complex could be used as an injectable and osteoconductive bone substitute material in many clinical situations.

本文言語English
ホスト出版物のタイトルBioceramics 24
出版社Trans Tech Publications Ltd
ページ296-299
ページ数4
1
ISBN(印刷版)9783037855171
DOI
出版ステータスPublished - 2013
イベント24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012 - Fukuoka, Japan
継続期間: 2012 10月 212012 10月 24

出版物シリーズ

名前Key Engineering Materials
番号1
529-530
ISSN(印刷版)1013-9826
ISSN(電子版)1662-9795

Other

Other24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012
国/地域Japan
CityFukuoka
Period12/10/2112/10/24

ASJC Scopus subject areas

  • 材料科学(全般)
  • 材料力学
  • 機械工学

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