Correlation of glomerular permeability, endothelial injury, and postoperative multiple organ dysfunction

Kaoru Koike, Junichi Aiboshi, Yotaro Shinozawa, Kazuhiko Sekine, Tomoyuki Endo, Yasuhiro Yamamoto

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Purpose. To determine whether the degree of microalbuminuria correlates with the extent of endothelial cell injury, the severity of illness, and the magnitude of multiple organ dysfunction in patients who undergo emergency surgery. Methods. We measured the urinary albumin: creatinine ratio (ACR) within 24h after surgery in 31 patients and examined its relationship with various clinical measurements. Results. The ACR increased during the first 24h post-operatively. The log ACR correlated with the serum thrombomodulin concentration measured on the same day, but not with the level of plasma von Willebrand factor antigen. The increase in the log ACR correlated with the acute physiology and chronic health evaluation score (APACHE III), the simplified acute physiology score, the multiple organ dysfunction score, and the score of sequential organ failure assessment (SOFA) calculated on the same day, and the blood volume lost during the operation. The log ACR did not correlate with the white blood cell count or the serum C-reactive protein measured at the same time. The log ACR correlated with SOFA on postoperative days 3, 7, and 10, and mortality increased in accordance with the increase in log ACR. Conclusions. The urinary ACR correlated with the extent of endothelial cell injury, the severity of illness, and the magnitude of multiple organ dysfunction.

本文言語English
ページ(範囲)811-816
ページ数6
ジャーナルSurgery today
34
10
DOI
出版ステータスPublished - 2004

ASJC Scopus subject areas

  • 外科

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