Cordybislactone, a stereoisomer of the 14-membered bislactone clonostachydiol, from the hopper pathogenic fungus Cordyceps sp. BCC 49294: Revision of the absolute configuration of clonostachydiol

Ken Ichi Ojima, Arunrat Yangchum, Pattiyaa Laksanacharoen, Kanoksri Tasanathai, Donnaya Thanakitpipattana, Hidetoshi Tokuyama, Masahiko Isaka

研究成果: Article査読

9 被引用数 (Scopus)

抄録

Cordybislactone (3), a new stereoisomer of the 14-membered bislactone clonostachydiol, together with its open ring analog (4), was isolated from the hopper pathogenic fungus Cordyceps sp. BCC 49294. The relative and absolute configurations of 3 were determined by chemical derivatizations, including the modified Mosher's method. The stereochemistry of clonostachydiol was determined using the natural compound isolated from Xylaria sp. BCC 4297. The result revealed that the absolute configuration of clonostachydiol, previously determined by synthesis, should be revised to its enantiomer.

本文言語English
ページ(範囲)351-358
ページ数8
ジャーナルJournal of Antibiotics
71
3
DOI
出版ステータスPublished - 2018 3月 1

ASJC Scopus subject areas

  • 薬理学
  • 創薬

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