Copper-catalyzed synthesis of 5-substituted 1H-tetrazoles via the [3+2] cycloaddition of nitriles and trimethylsilyl azide

Tienan Jin, Fukuzou Kitahara, Shin Kamijo, Yoshinori Yamamoto

研究成果: Article査読

174 被引用数 (Scopus)

抄録

The [3+2] cycloaddition between various nitriles and trimethylsilyl azide proceeds smoothly in the presence of a CuI catalyst in DMF/MeOH, to give the corresponding 5-substituted 1H-tetrazoles in good to high yields. The reaction most probably proceeds through the in situ formation of a copper azide species, followed by a successive [3+2] cycloaddition with the nitriles.

本文言語English
ページ(範囲)2824-2827
ページ数4
ジャーナルTetrahedron Letters
49
17
DOI
出版ステータスPublished - 2008 4 21

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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