Copper-catalyzed aerobic double functionalization of benzylic C(sp3)-H bonds for the synthesis of 3-hydroxyisoindolinones

Kanako Nozawa-Kumada; Yuta Matsuzawa; Kanako Ono; Masanori Shigeno; Yoshinori Kondo

doi:10.1039/d1cc02870g

Copper-catalyzed aerobic double functionalization of benzylic C(sp³)-H bonds for the synthesis of 3-hydroxyisoindolinones

Kanako Nozawa-Kumada, Yuta Matsuzawa, Kanako Ono, Masanori Shigeno, Yoshinori Kondo

薬学研究科・分子薬科学専攻

研究成果: Article › 査読

4 被引用数 (Scopus)

抄録

A copper-catalyzed aerobic 3-hydroxyisoindolinone synthesis was developed via the benzylic double C(sp3)-H functionalization of 2-alkylbenzamides. In this reaction, molecular oxygen was used as both an oxidant for C(sp3)-H functionalization and an oxygen source. Our method can be extended to diverse benzylic C(sp3)-H bonds and shows excellent functional group tolerance. This journal is

本文言語	English
ページ（範囲）	8604-8607
ページ数	4
ジャーナル	Chemical Communications
巻	57
号	69
DOI	https://doi.org/10.1039/d1cc02870g
出版ステータス	Published - 2021 9月 7

ASJC Scopus subject areas

触媒
電子材料、光学材料、および磁性材料
セラミックおよび複合材料
化学 (全般)
表面、皮膜および薄膜
金属および合金
材料化学

文献へのアクセス

10.1039/d1cc02870g

他のファイルとリンク

引用スタイル

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AU - Kondo, Yoshinori

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