Convenient synthesis of 2-substituted indoles from 2-ethynylanilines with tetrabutylammonium fluoride

Akito Yasuhara; Yuichi Kanamori; Masashi Kancko; Atsushi Numata; Yoshinori Kondo; Takao Sakamoto

doi:10.1039/a808842j

Convenient synthesis of 2-substituted indoles from 2-ethynylanilines with tetrabutylammonium fluoride

Akito Yasuhara, Yuichi Kanamori, Masashi Kancko, Atsushi Numata, Yoshinori Kondo, Takao Sakamoto

薬学研究科・分子薬科学専攻

研究成果: Article › 査読

123 被引用数 (Scopus)

抄録

The cyclization reaction of various 2-ethynylanilines, which were easily synthesized from 2-haloanilines by the palladium-catalyzed reaction with terminal alkynes, with tetrabutylammonium fluoride (TBAF) to yield 2-substituted indoles proceeded at refluxing or room temperature in THF in excellent yields without affecting the bromo, chloro, cyano, ethoxycarbonyl, and ethynyl groups.

本文言語	English
ページ（範囲）	529-534
ページ数	6
ジャーナル	Journal of the Chemical Society - Perkin Transactions 1
号	4
DOI	https://doi.org/10.1039/a808842j
出版ステータス	Published - 1999 1 1

ASJC Scopus subject areas

Chemistry(all)

文献へのアクセス

10.1039/a808842j

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引用スタイル

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AU - Kondo, Yoshinori

AU - Sakamoto, Takao

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