Convenient synthesis of 2-substituted indoles from 2-ethynylanilines with tetrabutylammonium fluoride

Akito Yasuhara, Yuichi Kanamori, Masashi Kancko, Atsushi Numata, Yoshinori Kondo, Takao Sakamoto

研究成果: Article査読

123 被引用数 (Scopus)

抄録

The cyclization reaction of various 2-ethynylanilines, which were easily synthesized from 2-haloanilines by the palladium-catalyzed reaction with terminal alkynes, with tetrabutylammonium fluoride (TBAF) to yield 2-substituted indoles proceeded at refluxing or room temperature in THF in excellent yields without affecting the bromo, chloro, cyano, ethoxycarbonyl, and ethynyl groups.

本文言語English
ページ(範囲)529-534
ページ数6
ジャーナルJournal of the Chemical Society - Perkin Transactions 1
4
DOI
出版ステータスPublished - 1999 1 1

ASJC Scopus subject areas

  • Chemistry(all)

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