Control of cell adhesion and functions using self-organized honey Comb-patterned polymer films

Masaru Tanaka, Akinori Tsuruma, Sadaaki Yamamoto, Masatsugu Shimomura

    研究成果: Conference contribution

    抄録

    The design of nano-and microstructures based on self-organization is a key area of research in the search for new biomaterials and biodevices,and such structures have a variety of potential applications in tissue engineering scaffolds and medical implants.3D scaffolds of appropriate pore size and porosities and with interconnected pores are required to facilitate cell adhesion, proliferation,differentiation,and eventual tissue regeneration in a natural manner.We have reported the honeycomb-patterned polymer film with highly regular pores that is formed by self-organization.The honeycomb films exerted a strong influence on cell morphology, proliferation,cytoskeleton, focal adhesion,and ECM production profiles.Our studies demonstrated that the neural stem / progenitor cells morphology,proliferation,and differentiation are controlled by the pore size of the honeycomb film.It is expected that the honeycomb films will have great potentials as biomaterials for tissue regeneration in a growth factor free proliferation process of stem cells.

    本文言語English
    ホスト出版物のタイトルBIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices
    ページ390-393
    ページ数4
    出版ステータスPublished - 2009 7 21
    イベント2nd International Conference on Biomedical Electronics and Devices, BIODEVICES 2009 - Porto, Portugal
    継続期間: 2009 1 142009 1 17

    出版物シリーズ

    名前BIODEVICES 2009 - Proceedings of the 2nd International Conference on Biomedical Electronics and Devices

    Other

    Other2nd International Conference on Biomedical Electronics and Devices, BIODEVICES 2009
    CountryPortugal
    CityPorto
    Period09/1/1409/1/17

    ASJC Scopus subject areas

    • Biomedical Engineering
    • Electrical and Electronic Engineering

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