TY - JOUR
T1 - Contrast-enhanced high-frequency ultrasound imaging of liver metastases in preclinical models
AU - Chen, Rui
AU - Tomita, Noriko
AU - Baba, Taisuke
AU - Oosawal, Fuki
AU - Watanabe, Yukiko
AU - Horie, Sachiko
AU - Mori, Shiro
AU - Fukumoto, Manabu
AU - Kodama, Tetsuya
PY - 2008/12/1
Y1 - 2008/12/1
N2 - Preclinical mouse models are essential to the study of liver metastasis, yet their utility has been limited by difficulty in tracking the progression of metastases through time. In this study, liver metastases were identified by in vivo bioluminescence system and a high-frequency ultrasound system with nanobubbles. Tumor grows and vessel densities were calculated. Liver metastases were observed on the second days after inoculation and confirmed by the HE staining. Vessels density in the liver metastasis group was increased compared to the control group. This study show that three-dimensional high-frequency ultrasound imaging combined with nanobubbles may be suited for early detection, quantitative assessment of metastatic progression in liver metastasis models.
AB - Preclinical mouse models are essential to the study of liver metastasis, yet their utility has been limited by difficulty in tracking the progression of metastases through time. In this study, liver metastases were identified by in vivo bioluminescence system and a high-frequency ultrasound system with nanobubbles. Tumor grows and vessel densities were calculated. Liver metastases were observed on the second days after inoculation and confirmed by the HE staining. Vessels density in the liver metastasis group was increased compared to the control group. This study show that three-dimensional high-frequency ultrasound imaging combined with nanobubbles may be suited for early detection, quantitative assessment of metastatic progression in liver metastasis models.
KW - High-frequency ultrasound
KW - In vivo bioluminescence system
KW - Liver metastasis
UR - http://www.scopus.com/inward/record.url?scp=67649383849&partnerID=8YFLogxK
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U2 - 10.1109/ULTSYM.2008.0427
DO - 10.1109/ULTSYM.2008.0427
M3 - Conference article
AN - SCOPUS:67649383849
SP - 1742
EP - 1744
JO - Proceedings - IEEE Ultrasonics Symposium
JF - Proceedings - IEEE Ultrasonics Symposium
SN - 1051-0117
M1 - 4803505
T2 - 2008 IEEE International Ultrasonics Symposium, IUS 2008
Y2 - 2 November 2008 through 5 November 2008
ER -