Contrast-enhanced high-frequency ultrasound imaging of liver metastases in preclinical models

Rui Chen, Noriko Tomita, Taisuke Baba, Fuki Oosawal, Yukiko Watanabe, Sachiko Horie, Shiro Mori, Manabu Fukumoto, Tetsuya Kodama

研究成果: Conference article査読

抄録

Preclinical mouse models are essential to the study of liver metastasis, yet their utility has been limited by difficulty in tracking the progression of metastases through time. In this study, liver metastases were identified by in vivo bioluminescence system and a high-frequency ultrasound system with nanobubbles. Tumor grows and vessel densities were calculated. Liver metastases were observed on the second days after inoculation and confirmed by the HE staining. Vessels density in the liver metastasis group was increased compared to the control group. This study show that three-dimensional high-frequency ultrasound imaging combined with nanobubbles may be suited for early detection, quantitative assessment of metastatic progression in liver metastasis models.

本文言語English
論文番号4803505
ページ(範囲)1742-1744
ページ数3
ジャーナルProceedings - IEEE Ultrasonics Symposium
DOI
出版ステータスPublished - 2008 12月 1
イベント2008 IEEE International Ultrasonics Symposium, IUS 2008 - Beijing, China
継続期間: 2008 11月 22008 11月 5

ASJC Scopus subject areas

  • 音響学および超音波学

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