Contraction of cross-linked actomyosin bundles

Natsuhiko Yoshinaga, Philippe Marcq

研究成果: Article査読

9 被引用数 (Scopus)

抄録

Cross-linked actomyosin bundles retract when severed in vivo by laser ablation, or when isolated from the cell and micromanipulated in vitro in the presence of ATP. We identify the timescale for contraction as a viscoelastic time τ, where the viscosity is due to (internal) protein friction. We obtain an estimate of the order of magnitude of the contraction time τ ≈ 10-100 s, consistent with available experimental data for circumferential microfilament bundles and stress fibers. Our results are supported by an exactly solvable, hydrodynamic model of a retracting bundle as a cylinder of isotropic, active matter, from which the order of magnitude of the active stress is estimated.

本文言語English
論文番号046004
ジャーナルPhysical Biology
9
4
DOI
出版ステータスPublished - 2012 8

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 分子生物学
  • 細胞生物学

フィンガープリント

「Contraction of cross-linked actomyosin bundles」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル