Contemporary strategies for the synthesis of Tetrahydropyran derivatives: Application to total synthesis of neopeltolide, a marine macrolide natural product

Haruhiko Fuwa

    研究成果: Article査読

    35 被引用数 (Scopus)

    抄録

    Tetrahydropyrans are structural motifs that are abundantly present in a range of biologically important marine natural products. As such, significant efforts have been paid to the development of efficient and versatile methods for the synthesis of tetrahydropyran derivatives. Neopeltolide, a potent antiproliferative marine natural product, has been an attractive target compound for synthetic chemists because of its complex structure comprised of a 14-membered macrolactone embedded with a tetrahydropyran ring, and twenty total and formal syntheses of this natural product have been reported so far. This review summarizes the total and formal syntheses of neopeltolide and its analogues, highlighting the synthetic strategies exploited for constructing the tetrahydropyran ring.

    本文言語English
    論文番号65
    ジャーナルMarine Drugs
    14
    4
    DOI
    出版ステータスPublished - 2016 4月

    ASJC Scopus subject areas

    • 創薬

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