Contact enhancement of locomotion in spreading cell colonies

Joseph D'alessandro, Alexandre P. Solon, Yoshinori Hayakawa, Christophe Anjard, François Detcheverry, Jean Paul Rieu, Charlotte Rivière

    研究成果: Article査読

    17 被引用数 (Scopus)

    抄録

    The dispersal of cells from an initially constrained location is a crucial aspect of many physiological phenomena, ranging from morphogenesis to tumour spreading. In such processes, cell-cell interactions may deeply alter the motion of single cells, and in turn the collective dynamics. While contact phenomena like contact inhibition of locomotion are known to come into play at high densities, here we focus on the little explored case of non-cohesive cells at moderate densities. We fully characterize the spreading of micropatterned colonies of Dictyostelium discoideum cells from the complete set of individual trajectories. From data analysis and simulation of an elementary model, we demonstrate that contact interactions act to speed up the early population spreading by promoting individual cells to a state of higher persistence, which constitutes an as-yet unreported contact enhancement of locomotion. Our findings also suggest that the current modelling paradigm of memoryless active particles may need to be extended to account for the history-dependent internal state of motile cells.

    本文言語English
    ページ(範囲)999-1005
    ページ数7
    ジャーナルNature Physics
    13
    10
    DOI
    出版ステータスPublished - 2017 10 4

    ASJC Scopus subject areas

    • 物理学および天文学(全般)

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