Construction of key building blocks towards the synthesis of cortistatins

Satrajit Indu, Rahul D. Telore, Krishna P. Kaliappan

研究成果: Article査読

2 被引用数 (Scopus)

抄録

This work reports the construction of key building blocks towards the synthesis of cortistatins; a family of steroidal alkaloids. Cortistatin A, being a primary target due to its superior biological properties over other congeners, has been prepared by two different synthetic routes. Synthesis of the precursor to the heavily substituted A-ring starting from d-glucose and construction of the DE-ring junction employing a Hajos-Parrish ketone as a chiral pool have been demonstrated. Efforts are underway to assemble these key fragments and build towards the total synthesis of cortistatin A.

本文言語English
ページ(範囲)2432-2446
ページ数15
ジャーナルOrganic and Biomolecular Chemistry
18
13
DOI
出版ステータスPublished - 2020 4 7
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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