Fluorinated compounds have drawn the attention of medicinal chemists because of their potential metabolic tolerance and modulation of drug efficacy. Thus stereo- and enantioselective construction of fluorinated carbon center is an important issue. In spite of remarkable progress in the last decade, the first effective method of catalytic enantioselective fluorination by nucleophilic fluorine reagent has been reported in this year. In this article, construction of fluorinated chiral center is reviewed being categolized into three classes.
|ジャーナル||Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry|
|出版ステータス||Published - 2010 9|
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