Constitutive expression of aryl hydrocarbon receptor in keratinocytes causes inflammatory skin lesions

Masafumi Tauchi, Azumi Hida, Takaaki Negishi, Fumiki Katsuoka, Shuhei Noda, Junsei Mimura, Tomonori Hosoya, Akinori Yanaka, Hiroyuki Aburatani, Yoshiaki Fujii-Kuriyama, Hozumi Motohashi, Masayuki Yamamoto

研究成果: Article査読

124 被引用数 (Scopus)

抄録

Occupational and environmental exposure to polycyclic aromatic hydrocarbons (PAHs) has been suggested to provoke inflammatory and/or allergic disorders, including asthma, rhinitis, and dermatitis. The molecular mechanisms of this PAH-mediated inflammation remain to be clarified. Previous studies implied the involvement of PAHs as irritants and allergens, with the reactive oxygen species generated from the oxygenated PAHs believed to be an exacerbating factor. It is also possible that PAHs contribute to the pathogenesis through activation of aryl-hydrocarbon receptor (AhR)-mediated transcription, since PAHs are potent inducers of the AhR. To address this point, we generated transgenic mouse lines expressing the constitutive active form of the AhR in keratinocytes. In these lines of mice, the AhR activity was constitutively enhanced in the absence of ligands, so that any other direct elects of PAHs and their metabolites could be ignored. At birth, these transgenic mice were normal, but severe skin lesions with itching developed postnatally. The skin lesions were accompanied by inflammation and immunological imbalance and resembled typical atopic dermatitis. We demonstrate that constitutive activation of the AhR pathway causes inflammatory skin lesions and suggests a new mechanism for the exacerbation of inflammatory diseases after exposure to occupational and environmental xenobiotics.

本文言語English
ページ(範囲)9360-9368
ページ数9
ジャーナルMolecular and cellular biology
25
21
DOI
出版ステータスPublished - 2005 11
外部発表はい

ASJC Scopus subject areas

  • 分子生物学
  • 細胞生物学

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