Conformational restriction of cyclic dinucleotides with triazole-linked cyclophane analogues

Tomoko Fujino, Koudai Okada, Hiroyuki Isobe

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Cyclic dinucleotides (CDN) such as c-di-GMP and c-di-AMP are important multi-functional compounds that regulate a diverse range of processes in bacteria. The diversity of the functions is enabled by the two distinct conformations, that is, open and close conformations. We herein report the concise synthesis of triazole-linked analogues (c-di-GMPTL, c-di-AMPTL) through click dimerization of nucleoside analogues. The implementation of a cyclophane system in the central macrocycle furnished the structure with the conformational restriction to maintain the structure similar to the open conformer of natural congeners.

本文言語English
ページ(範囲)2659-2661
ページ数3
ジャーナルTetrahedron Letters
55
16
DOI
出版ステータスPublished - 2014 4月 16
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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