抄録
3-Substituted 5-(tributylstannyl)isoxazoles were newly synthesized by the 1,3-dipolar cyctoadditton of nitrile oxides to tributylethynylstannane. The iodination and the palladium-catalyzed benzoylation of 5-(tributylstannyl)-3-methylisoxazolegave 5-iodo-3-methylisoxazole and 3-methyl-5-isoxazolyl phenyl ketone in satisfactory yields, respectively. The palladium-catalyzed cross-coupling reaction of the stannylisoxazole with 2-bromonitrobenzene followed by the catalytic hydrogenation over Raney nickel resulted in the formation of 2-methyll-4(1H)-quinolinone in 57% overall yield.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 5111-5118 |
| ページ数 | 8 |
| ジャーナル | Tetrahedron |
| 巻 | 47 |
| 号 | 28 |
| DOI | |
| 出版ステータス | Published - 1991 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry