Condensed Heteroaromatic Ring Systems. V. Formal Synthesis of Matrine and Related Compounds Using Palladium-Catalyzed Carbon-Carbon Bond Formations as Key Reactions

Takao Sakamoto, Norio Miura, Yoshinori Kondo, Hiroshi Yamanaka

研究成果: Article査読

19 被引用数 (Scopus)

抄録

The iodination and subsequent dehydroxychlorination of l,6-naphthyridin-5(6H)-one gave 5-chloro-8-iodo-1,6-naphthyridine, which was converted to the 5-methoxy derivative. Starting from this compound, didehydromatrine was synthesized by using palladium-catalyzed cross-coupling reactions with ethyl acrylate and 3-butyn-l-ol, as key reactions. Similarly, nordehydro-α-matrinidine was synthesized through four steps from 8-bromo-l,6-naphthyridine, obtained by the bromination of unsubstituted 1,6-naphthyridine.

本文言語English
ページ(範囲)2018-2023
ページ数6
ジャーナルChemical and Pharmaceutical Bulletin
34
5
DOI
出版ステータスPublished - 1986 1月 1

ASJC Scopus subject areas

  • 化学 (全般)
  • 創薬

フィンガープリント

「Condensed Heteroaromatic Ring Systems. V. Formal Synthesis of Matrine and Related Compounds Using Palladium-Catalyzed Carbon-Carbon Bond Formations as Key Reactions」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル