Concise synthesis of CC-1065/duocarmycin pharmacophore using the intramolecular heck reaction

Takao Sakamoto; Yoshinori Kondo; Masanobu Uchiyama; Hiroshi Yamanaka

doi:10.1039/p19930001941

Concise synthesis of CC-1065/duocarmycin pharmacophore using the intramolecular heck reaction

Takao Sakamoto, Yoshinori Kondo, Masanobu Uchiyama, Hiroshi Yamanaka

薬学研究科・分子薬科学専攻

研究成果: Article › 査読

64 被引用数 (Scopus)

抄録

3-Methyleneindoline derivatives were synthesized by intramolecular Heck reaction of N-allyl-2-iodoaniline derivatives in the presence of Ag ₂CO₃. This method was successfully applied to the synthesis of the CC-1065/duocarmycin pharmacophore.

本文言語	English
ページ（範囲）	1941-1942
ページ数	2
ジャーナル	Journal of the Chemical Society, Perkin Transactions 1
号	17
DOI	https://doi.org/10.1039/p19930001941
出版ステータス	Published - 1993 1月 1

ASJC Scopus subject areas

化学 (全般)

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10.1039/p19930001941

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引用スタイル

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title = "Concise synthesis of CC-1065/duocarmycin pharmacophore using the intramolecular heck reaction",

abstract = "3-Methyleneindoline derivatives were synthesized by intramolecular Heck reaction of N-allyl-2-iodoaniline derivatives in the presence of Ag 2CO3. This method was successfully applied to the synthesis of the CC-1065/duocarmycin pharmacophore.",

author = "Takao Sakamoto and Yoshinori Kondo and Masanobu Uchiyama and Hiroshi Yamanaka",

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Concise synthesis of CC-1065/duocarmycin pharmacophore using the intramolecular heck reaction

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