Computer simulation of formation and collapse of primary thrombus due to platelet aggregation using particle method

Hiroki Kamada, Ken Ichi Tsubota, Shigeo Wada, Takami Yamaguchi

研究成果: Article査読

8 被引用数 (Scopus)

抄録

The purpose of this study is to propose a computer simulation method using particle method to analyze the formation and collapse of primary thrombus due to platelet aggregation in the blood flow. In the employed particle method, the blood region was discretized by particles that were assumed to have the characteristics of plasma and platelet. The MPS method that was developed for incompressible viscous flow was applied to the plasma flow. It was assumed that the platelets stochastically aggregate to the injured wall, and that the probability is expressed by hypothetic attractive force. In addition, spring force was introduced to express the deformation of the aggregated thrombus as a solid like material. Two-dimensional simulations revealed that the proposed method reproduced initial thrombogenesis, growth of the thrombus, and its destruction. The blood flow rate influenced not only the amount of the aggregated platelets, but also the speed of the formation of a thrombus and the duration until a thrombus collapsed. These results demonstrated that the proposed method is useful to investigate the process of primary thrombogenesis which is regulated under the influence of fluid mechanical factors.

本文言語English
ページ(範囲)1109-1115
ページ数7
ジャーナルNihon Kikai Gakkai Ronbunshu, B Hen/Transactions of the Japan Society of Mechanical Engineers, Part B
72
5
DOI
出版ステータスPublished - 2006

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Mechanical Engineering

フィンガープリント 「Computer simulation of formation and collapse of primary thrombus due to platelet aggregation using particle method」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル